D141
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D141
Sigma
Digitonin
| Synonym: | Digitin |
| CAS Number: | 11024-24-1 |
| Linear Formula: | C56H92O29 |
| Molecular Weight: | 1229.31 |
| Beilstein Registry Number: | 78654 |
| EC Number: | 234-255-6 |
| MDL number: | MFCD00077729 |
| PubChem Substance ID: | 24893429 |
Description
| Frequently Asked Questions | Live Chat and Frequently Asked Questions are available for this Product. |
| Application | Mild nonionic detergent used to solubilize receptors and permeabilize cellular and nuclear membranes. |
| Quality | Preparation is free of water-insoluble constituents. |
Properties
| optical activity | [α]20/D −54°, c = 2.8 in methanol(lit.) |
| mol wt | micellar avg mol wt 70,000 |
| aggregation number | 60 |
| color | white |
| CMC | <0.5 mM(20-25°C) |
| mp | 230-240 °C (dec.)(lit.) |
| solubility | H2O: ~5 % (w/v) solubilized by heating to 95 °C - 98 °C and then cooling to room temp. |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 22-28-36/37-45 |
| RIDADR | UN3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | IH2050050 |
References
| reference | Karl, J., et al., GFAP phosphorylation studied in digitonin-permeabilized astrocytes: standardization of conditions. Brain Res. 853, 32-40, (2000) Abstract |
| Liu, J., et al., Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking. Methods 19, 403, (1999) Abstract | |
| Prehm, S., et al., A mild purification method for polysaccharide binding membrane proteins: phase separation of digitonin extracts to isolate the hyaluronate synthase from Streptococcus sp. in active form. Protein Expr. Purif. 7, 343-346, (1996) Abstract | |
| Nock, B., Extracti-Gel D chromatography is a simple efficient method for removing digitonin during receptor purification: application to the κ1 opioid receptor. J. Neurosci. Methods 50, 353, (1993) Abstract | |
| Merck | Merck 13,3183 |
| Beilstein | Beil. 19,V,3,603 |
| Aldrich MSDS 1, 695:B / Corp MSDS 1 (1), 1253:C / RegBook 1 (2), 2857:E / Sax 6, 1035 / Sigma FT-IR 1 (1), 584:D |
